Publications

Lakatos P, Hegedűs Cs, Ayestarán NS, Juarranz Á, Kövér EK, Szabó É, Virág L: The PARP inhibiton PJ-34 sensitizes cells to UVA-induced phototoxicity by a PARP independent mechanism. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 79, 31-40 (2016)

Géhl Zs, Bakondi E, Resch MD, Hegedűs Cs, Kovács K, Lakatos P, Szabó A, Nagy Z, Virág L: Diabetes-induced oxidative stress in the vitreous humor. Redox Biology 9, 100-103 (2016)

Rodriguez-Vargas JM, Rodriguez MI, Majuelos-Melguizo J, Garcia-Diaz A, Gonzalez-Flores A, Lopez-Rivas A, Virág L, Illuzzi G, Schreiber V, Dantzer F, Oliver FJ: Autophagy requires poly(adp-ribosyl)ation-dependent AMPK nuclear export. Cell Death and Differentiation 1-12 (2016)

Brunyánszki A, Szczesny B, Virág L, Szabó C: Mitochondrial poly(ADP-ribose) polymerase: the Wizard of Oz at work. Free Radical Biology and Medicine 100, 257-270 (2016)

Virág L: A védőenzimi is árthat - A sokarcú sejthalál és a PARP1 karrierje. Élet és Tudomány 25, 777-779 (2016)

Dedinszki D, Sipos A, Kiss A, Bátori R, Kónya Z, Virág L, Erdődi F, Lontay B: Protein phosphatase-1 is involved in the maintenance of normal homeostasis and in UVA irradiation-induced pathological alterations in HaCaT cells and in mouse skin. Biochimica et Biophysica Acta - Molecular Basis of Disease 1852, 22-33 (2015)

Kiss B, Szántó M, Szklenár M, Brunyánszki A, Marosvölgyi T, Sárosi E, Remenyik É, Gergely P, Virág L, Decsi T, Rühl R, Bai P: Poly(ADP) ribose polymerase-1 ablation alters eicosanoid and docosanoid signaling and metabolism in a murine model of contact hypersensitivity. Molecular Medicine Reports 11, 2861-2867 (2015)

Hegedűs Cs, Robaszkiewicz A, Lakatos P, Szabó É, Virág L.: Poly(ADP-ribose) in the bone: from oxidative stress signal to structural element. Free Radical Biology and Medicine 82, 179-186 (2015)

Gegely Sz, Hegedűs Cs, Lakatos P, Kovács K, Gáspár R, Csont T, Virág L: High throught screening identifies a novel compund protecting cardiomyocytes from doxorubicin-induced damage. Oxidative Medicine and Cellular Longevity 2015, 1-5 (2015)

Szántó M, Brunyánszki A, Márton J, Vámosi G, Nagy L,  Fodor T, Kiss B, Virág L, Gergely P, Bai P. Deletion of PARP-2 induces hepatic cholesterol accumulation and decrease in HDL levels. Biochim. Biophys. Acta (Molecular Basic of Disease) 1842, 594-602 (2014)

Csóka B, Koscsó B, Törő G, Kókai E, Virág L, Németh ZH, Pacher P, Bai P, Haskó G: A2B adenosine receptors prevent adipose tissue inflammation and insulin resistance by maintaining alternative macrophage activation. Diabetes 63(3), 850-866 (2014)

Hegedűs Cs, Virág L: Inputs and outputs of poly(ADP-ribosyl)ation: relevance to oxidative stress. Redox Biology 2, 978-982 (2014)

El-Hamoy T, Hegedűs Cs, Lakatos P, Kovács K, bai P, El-Ghazaly MA, El-Denshary ES, Szabó É, Virág L: Activation of poly(ADP-ribose) polymerase-1 delays wound healing by regulating keratinocyte migration and production of inflammatory mediators. Molecular Medicine 20, 363-371 (2014)

Robeszkiewicz A, Valkó Zs, Kovács K, Hegedűs Cs, Bakondi E, Bai P, Virág L: The role of p83 signaling and poly(ADP-ribosyl)ation-induced metabolic collapse in the osteogenic differentiationi-coupled cell. Free Radical Biology and Medicine 76, 69-79 (2014)

Nagy L, Docsa T, Szántó M, Brunyánszki A, Hegedűs C, Márton J, Kónya B, Virág L, Somsák L, Gergely P, Bai P.: Glycogen Phosphorylase Inhibitor N-(3,5-Dimethyl-Benzoyl)-N'-(β-D-Glucopyranosyl)Urea Improves Glucose Tolerance under Normoglycemic and Diabetic Conditions and Rearranges Hepatic Metabolism. PLoS One. 2013 Jul 25;8(7):e69420. (2013)

Koscsó B, Csóka B, Kókai E, Németh ZH, Pacher P, Virág L, Leibovich SJ, Haskó G.: Adenosine augments IL-10-induced STAT3 signaling in M2c macrophages. J Leukoc Biol. 94(6): 1309-1315 (2013)

Oit-Wiscombe I, Virag L, Soomets U, Altraja A.: Increased DNA Damage in Progression Of COPD: A Response By Poly(ADP-Ribose) Polymerase-1. PLoS One. 2013 Jul 24;8(7):e70333, 8 p. (2013)

Virág L.: 50Years of poly(ADP-ribosyl)ation. Mol Aspects Med. 34(6): 1043-1045 (2013),  doi:pii: S0098-2997(13)00039-3. 10.1016/j.mam.2013.05.002.

Erdélyi K, Pacher P, Virág L, Szabó C.: Role of poly(ADP-ribosyl)ation in a 'two-hit' model of hypoxia and oxidative stress in human A549 epithelial cells in vitro. Int J Mol Med. 32(2): 339-346 (2013)  doi: 10.3892/ijmm.2013.1397.

Hegedűs C, Lakatos P, Kiss-Szikszai A, Patonay T, Gergely S, Gregus A, Bai P, Haskó G, Szabó É, Virág L : Cytoprotective dibenzoylmethane derivatives protect cells from oxidative stress-induced necrotic cell death. Pharmacol Res. 2013Jun;72:25-34. doi: 10.1016/j.phrs.2013.03.002. (2013)

Palicz Z, Jenes A, Gáll T, Miszti-Blasius K, Kollár S, Kovács I, Emri M, Márián T, Leiter E, Pócsi I, Csősz E, Kalló G, Hegedűs C, Virág L, Csernoch L, Szentesi P.: In vivo application of a small molecular weight antifungal protein of Penicillium chrysogenum (PAF). Toxicol Appl Pharmacol. 2013 May 15;269(1):8-16. (2013)

Virág L, Robaszkiewicz A, Vargas JM, Javier Oliver F.: Poly(ADP-ribose) signaling in cell death. Mol Aspects Med. 34(6): 1153-1167 (2013) doi:pii: S0098-2997(13)00008-3. 10.1016/j.mam.2013.01.007.

Bürkle A, Virág L.: Poly(ADP-ribose): Paradigms and paradoxes. Mol Aspects Med.  34(6), 1046-1065 (2013). doi:pii: S0098-2997(12)00157-4. 10.1016/j.mam.2012.12.010.

Lakatos P, Szabó E, Hegedűs C, Haskó G, Gergely P, Bai P, Virág L:. 3-Aminobenzamide protects primary human keratinocytes from UV-induced cell death by a poly(ADP-ribosyl)ation independent mechanism. Biochim Biophys Acta. 2013 Mar;1833(3):743-51. (2013)

Bai P, Virág L.: Role of poly(ADP-ribose) polymerases in the regulation of inflammatory processes. FEBS Lett. 2012 Nov 2;586(21):3771-7. (2012)

Kovács K, Erdélyi K, Hegedűs C, Lakatos P, Regdon Z, Bai P, Haskó G, Szabó E, Virág L.:  Poly(ADP-ribosyl)ation is a survival mechanism in cigarette smoke-induced and hydrogen peroxide-mediated cell death. Free Radic Biol Med. 2012 Nov 1;53(9):1680-8. (2012)

Robaszkiewicz A, Erdélyi K, Kovács K, Kovács I, Bai P, Rajnavölgyi E, Virág L.: Hydrogen peroxide-induced poly(ADP-ribosyl)ation regulates osteogenic differentiation-associated cell death. Free Radic Biol Med. 2012 Oct 15;53(8):1552-64. (2012)

Szántó M, Brunyánszki A, Kiss B, Nagy L, Gergely P, Virág L, Bai P.: Poly(ADP-ribose) polymerase-2: emerging transcriptional roles of a DNA-repair protein. Cell Mol Life Sci. 2012 Dec;69(24):4079-92. (2012)

Géhl Zs*, Bai P*, Bodnár E, Emri G, Remenyik É, Németh J, Gergely P, Virág L, Szabó É: Poly(ADP-ribose) in the skin and in malignant melanomas. HISTOLOGY AND HISTOPATHOLOGY 2012 May;27(5):651-9. (2012)

Koscsó B, Csóka B, Selmeczy Zs, Himer L, Pacher P, Virág L, Haskó G: Adenosine augments IL-10 production by microglial cells through an A2B adenosine receptor-mediated process. JOURNAL OF IMMUNOLOGY 188: pp. 445-453. (2012)

Szántó M*, Rutkai I*, Hegedűs Cs, Czikora Á, Rózsahegyi M, Kiss B, Virág L, Gergely P, Tóth A, Bai P: Poly(ADP-ribose) polymerase-2 depletion reduces doxorubicin-induced damage through SIRT1 induction. CARDIOVASCULAR RESEARCH 92:(3) pp. 430-438. (2011)

Szabó É, Kovács I, Grune T, Haczku A, Virág L: PARP-1: a new player in the asthma field? ALLERGY 66: pp. 811-814. (2011)

Haskó Gy, Csóka B, Koscsó B, Chandra R, Pacher P, Thompson LF, Deitch EA, Spolarics Z, Virág L, Gergely P, Rolandelli RH, Németh ZH: Ecto-5’-nucleotidase (CD73) decreases mortality and organ injury in sepsis. JOURNAL OF IMMUNOLOGY 187: pp. 4256-4267. (2011)

 

 

Erdèlyi K, Kiss A, Bakondi E, Bai P, Szabó C, Gergely P, Erdödi F, Virag L.
Gallotannin inhibits the expression of chemokines and inflammatory cytokines in A549 cells.
Mol Pharmacol., 2005 Sep;68(3):895-904.

L. Virág:
The expanding universe of poly(ADP-ribosyl)ation
CMLS, Cell. Mol. Life Sci. 62 (2005)

K. Erdélyi, E. Bakondi, P. Gergely, C. Szabó, L. Virág:
Pathophysiologic role of oxidative stress-induced poly(ADP-ribose) polymerase-1 activation: focus on cell death and transcriptional regulation
CMLS, Cell. Mol. Life Sci. 62 (2005)

L. Virág:
Poly(ADP-ribosyl)ation in asthma and other lung disease
Pharmacological Research 52, 83-92 (2005)

Csóka B, Németh ZH, Virág L, Gergely P, Leibovich SJ, Pacher P, Sun CX, Blackburn MR, Vizi ES, Deitch EA, Haskó G.
A2A adenosine receptors and C/EBPbeta are crucially required for IL-10 production
by macrophages exposed to Escherichia coli. Blood. 2007 Oct 1;110(7):2685-95. Epub 2007 May 24.

Bai P., Hegedűs C., Erdelyi K., Szabó E., Bakondi E., Gergely S., Szabó C., Virág L.
Protein tyrosine nitration and poly(ADP-ribose) polymerase activation in N-methyl-N- nitro-N-nitrosoguanidine-treated thymocytes: Implication for cytotoxicity
Toxicol Lett, 2007.

Zakany R., Bakondi E., Juhasz T., Matta C., Szijgyártó Z., Erdelyi K., Szabó E., Modis L., Virág L., Gergely P.
Oxidative stress-induced poly(ADP-ribosyl)ation in chick limb bud-derived chondrocytes
Int J Mol Med, 2007. 4:597-605

Hegedus C, Lakatos P, Oláh G, Tóth BI, Gergely P, Szabó E, Bíró T, Szabó C, Virág L.
Protein kinase C protects from DNA damage-induced necrotic cell death by inhibiting poly(ADP-ribose) polymerase-1.
FEBS Lett. 2008 May 28;582(12):1672-8. Epub 2008 Apr 24.

Erdélyi K, Bai P, Kovács I, Szabó E, Mocsár G, Kakuk A, Szabó C, Gergely P, Virág L.
Dual role of poly(ADP-ribose) glycohydrolase in the regulation of cell death in oxidatively stressed A549 cells.
FASEB J. 2009 Oct;23(10):3553-63. Epub 2009 Jul 1.

Bai P, Hegedus C, Szabó E, Gyüre L, Bakondi E, Brunyánszki A, Gergely P, Szabó C, Virág L.
Poly(ADP-ribose) polymerase mediates inflammation in a mouse model of contact hypersensitivity.
J Invest Dermatol. 2009 Jan;129(1):234-8. Epub 2008 Jul 17.

Related documents

Virag L, Scott GS, Antal-Szalmas P, O'Connor M, Ohshima H, Szabo C. Requirement of intracellular calcium mobilization for peroxynitrite-induced poly(ADP-ribose) synthetase activation and cytotoxicity. Mol Pharmacol. 1999 Oct;56(4):824-33.

Whalen MJ, Clark RS, Dixon CE, Robichaud P, Marion DW, Vagni V, Graham SH, Virag L, Hasko G, Stachlewitz R, Szabo C, Kochanek PM. Reduction of cognitive and motor deficits after traumatic brain injury in mice deficient in poly(ADP-ribose) polymerase. J Cereb Blood Flow Metab. 1999 Aug;19(8):835-42.

Virag L, Szabo C. Inhibition of poly(ADP-ribose) synthetase (PARS) and protection against peroxynitrite-induced cytotoxicity by zinc chelation. Br J Pharmacol. 1999 Feb;126(3):769-77.

Ajuebor MN, Das AM, Virag L, Szab, Perretti M. Regulation of macrophage inflammatory protein-1 alpha expression and function by endogenous interleukin-10 in a model of acute inflammation. Biochem Biophys Res Commun. 1999 Feb 16;255(2):279-82.

Ajuebor MN, Das AM, Virag L, Flower RJ, Szabo C, Perretti M. Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: evidence for an inhibitory loop involving endogenous IL-10. J Immunol. 1999 Feb 1;162(3):1685-91.

Virag L, Szabo C. BCL-2 protects peroxynitrite-treated thymocytes from poly(ADP-ribose) synthase (PARS)-independent apoptotic but not from PARS-mediated necrotic cell death. Free Radic Biol Med. 2000 Oct 15;29(8):704-13.

Whalen MJ, Clark RS, Dixon CE, Robichaud P, Marion DW, Vagni V, Graham S, Virag L, Hasko G, Stachlewitz R, Szabo C, Kochanek PM. Traumatic brain injury in mice deficient in poly-ADP(ribose) polymerase: a preliminary report. Acta Neurochir Suppl. 2000;76:61-4.

Liaudet L, Soriano FG, Szabo E, Virag L, Mabley JG, Salzman AL, Szabo C. Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose)polymerase. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10203-8.

Hasko G, Kuhel DG, Nemeth ZH, Mabley JG, Stachlewitz RF, Virag L, Lohinai Z, Southan GJ, Salzman AL, Szabo C. Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock. J Immunol. 2000 Jan 15;164(2):1013-9.

Bai P, Bakondi E, Szabo E, Gergely P, Szabo C, Virag L. Partial protection by poly(ADP-ribose) polymerase inhibitors from nitroxyl-induced cytotoxity in thymocytes. Free Radic Biol Med. 2001 Dec 15;31(12):1616-23.

Mabley JG, Jagtap P, Perretti M, Getting SJ, Salzman AL, Virag L, Szabo E, Soriano FG, Liaudet L, Abdelkarim GE, Hasko G, Marton A, Southan GJ, Szabo C. Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase. Inflamm Res. 2001 Nov;50(11):561-9.

Soriano FG, Virag L, Szabo C. Diabetic endothelial dysfunction: role of reactive oxygen and nitrogen species production and poly(ADP-ribose) polymerase activation. J Mol Med. 2001 Aug;79(8):437-48. Review.

Liaudet L, Szabo E, Timashpolsky L, Virag L, Cziraki A, Szabo C. Suppression of poly (ADP-ribose) polymerase activation by 3-aminobenzamide in a rat model of myocardial infarction: long-term morphological and functional consequences. Br J Pharmacol. 2001 Aug;133(8):1424-30.

Szabo E, Virag L, Bakondi E, Gyure L, Hasko G, Bai P, Hunyadi J, Gergely P, Szabo C. Peroxynitrite production, DNA breakage, and poly(ADP-ribose) polymerase activation in a mouse model of oxazolone-induced contact hypersensitivity. J Invest Dermatol. 2001 Jul;117(1):74-80.

Scott GS, Hake P, Kean RB, Virag L, Szabo C, Hooper DC. Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis. J Neuroimmunol. 2001 Jul 2;117(1-2):78-86.

Lohinai Z, Stachlewitz R, Virag L, Szekely AD, Hasko G, Szabo C. Evidence for reactive nitrogen species formation in the gingivomucosal tissue. J Dent Res. 2001 Feb;80(2):470-5.

Soejima K, Traber LD, Schmalstieg FC, Hawkins H, Jodoin JM, Szabo C, Szabo E, Virag L, Salzman A, Traber DL. Role of nitric oxide in vascular permeability after combined burns and smoke inhalation injury. Am J Respir Crit Care Med. 2001 Mar;163(3 Pt 1):745-52.

Virag L, Szabo C. Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15(1):99-107.

Eaves-Pyles T, Murthy K, Liaudet L, Virag L, Ross G, Soriano FG, Szabo C, Salzman AL. Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction. J Immunol. 2001 Jan 15;166(2):1248-60.

Soriano GF, Virag L, Jagtap P, Szabo E, Mabley JG, Liaudet L, Marton A, Hoyt DG, Murthy KG, Salzman AL, Southan GJ, Szabo C. Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation. Nat Med. 2001 Jan;7(1):108-13.

Szabó C, Mabley JG, Moeller SM, Shimanovich R, Pacher P, Virág L, Soriano FG, Van Duzer JH, Williams W, Salzman AL, and GrovesJT. Pathogenetic role of peroxynitrite in the development of diabetes and diabetic vascular complications: studies with FP15, a novel potent peroxynitrite decomposition catalyst. Molecular Medicine 8.10 (2002) 571-580

Kirov MY, Evgenov OV, Kuklin VN, Virag L, Pacher P, Southan GJ, Salzman AL, Szabo C, Bjertnaes LJ. Aerosolized Linear Polyethylenimine-Nitric Oxide/Nucleophile Adduct Attenuates Endotoxin-induced Lung Injury in Sheep. Am J Respir Crit Care Med 2002 Dec 1;166(11):1436-42

Virág L and Szabó C: The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacological Reviews 54:375- 429, 2002.

Virág L, Szabó É, Bakondi E, Bai P, Gergely P, Hunyadi J, Szabó C: The nitric oxide - peroxynitrite - poly(ADP-ribose) polymerase pathway in the skin (Minireview) Exp. Dermatol. 11:189-202, 2002.

Goldfarb RD, Marton A, Szabó E, Virág L, Salzman AL, Glock D, Akhter I, McCarthy R, Parrillo JE, Szabó C. Protective effect of a novel, potent inhibitor of poly(adenosine 5’-diphosphate-ribose) synthetase in a porcine model of severe bacterial sepsis. Crit. Care. Med 30:974-980, 2002

Jagtap P, Soriano FG, Virág L, Liaudet L, Mabley J, Szabó E, Haskó G, Marton A, Lorigados CB, Gallyas F. Jr, Sümegi B, Hoyt DG, Baloglu E, VanDuzer J, Salzman AL, Southan, GJ, Szabó C. Novel phenanthridinone inhibitors of poly (adenosine 5’-diphosphate-ribose) synthetase: Potent cytoprotective and antishock agents. Crit. Care. Med 30: 1071-1082, 2002

Soriano FG, Liaudet L, Szabo E, Virág L, Mabley JG, Pacher P, Szabó C: Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient mice. Shock 17(4):286-92, 2002

Pacher P, Liaudet L, Bai P, Virág L, Mabley J, Haskó G, Szabó C: Activation of poly(ADP-ribose) polymerase contributes to the development of doxorubicin-induced heart failure. J. Pharmacol. Exp. Therap. 300(3):862-7, 2002.

Faro R, Toyoda Y, McCully JD, Jagtap P, Szabó E, Virág L, Bianchi C, Levitsky S, Szabó C, and Sellke FW Myocardial protection by PJ34, a novel potent poly (ADP-ribose) synthetase inhibitor. Ann. Thor. Surg. 73(2):575-581, 2002.

Liaudet L, Pacher P, Mabley JG, Virag L, Soriano FG, Hasko G, Szabo C. Activation of Poly(ADP-Ribose) Polymerase-1 Is a Central Mechanism of Lipopolysaccharide-Induced Acute Lung Inflammation. Am J Respir Crit Care Med. 2002 Feb 1;165(3):372-377.

Bakondi E, Bai P, Szabo E E, Hunyadi J, Gergely P, Szabo C, Virag L. Detection of poly(ADP-ribose) polymerase activation in oxidatively stressed cells and tissues using biotinylated NAD substrate. J Histochem Cytochem. 2002 Jan;50(1):91-8.

Németh ZH, Leibovich J, Deitch EA, Sperlágh B, Virág L, Vízi SE, Szabó C, Haskó G: Adenosine stimulates CREB activation in macrophages via p38 MAPK-mediated mechanism. Biochem. Biophys. Res. Commun. 312(4):883-8, 2003.

Bakondi E, Gönczi M, Szabó É, Bai P, Pacher P, Gergely P, Kovács L, Hunyadi J, Szabó C, Csernoch L, Virág L. Role of intracellular calcium mobilization and cell density-dependent signaling in oxidative stress-induced cytotoxicity in HaCaT keratinocytes. J. Invest. Dermatol. 121:88-95, 2003.

Virág L, Szabó É, Gergely P, Szabó C: Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention. Toxicology Letters, Volumes 140-141:113-124, 2003.

Pacher P, Liaudet L, Bai P, Mabley JG, Kaminski PM, Virág L, Deb A, Szabó É, Ungvári Z, Wolin MS, Szabó C.A potent peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction. Circulation 107:896-904

Liaudet L, Szabó C, Evgenov O, Murthy KG, Pacher P, Virág L, Mabley J, Marton A, Soriano FG, Kirov M, Bjertnaes LJ, Salzman AL (2003) Flagellin from gram-negative bacteria is a potent mediator of acute pulmonary inflammation in sepsis. Shock, 19: 131-137.

Scott GS, Virag L, Szabo C, Hooper DC. Peroxynitrite-induced oligodendrocyte toxicity is not dependent on poly(ADP-ribose) polymerase activation. Glia 2003 Jan 15;41(2):105-116

Németh ZH, Leibovich J, Deitch EA, Sperlágh B, Virág L, Vízi SE, Szabó C, Haskó G: Adenosine stimulates CREB activation in macrophages via p38 MAPK-mediated mechanism. Biochem. Biophys. Res. Commun. 312(4):883-8, 2003.

Bakondi E, Gönczi M, Szabó É, Bai P, Pacher P, Gergely P, Kovács L, Hunyadi J, Szabó C, Csernoch L, Virág L. Role of intracellular calcium mobilization and cell density-dependent signaling in oxidative stress-induced cytotoxicity in HaCaT keratinocytes. J. Invest. Dermatol. 121:88-95, 2003.

Virág L, Szabó É, Gergely P, Szabó C: Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention. Toxicology Letters, Volumes 140-141:113-124, 2003.

Pacher P, Liaudet L, Bai P, Mabley JG, Kaminski PM, Virág L, Deb A, Szabó É, Ungvári Z, Wolin MS, Szabó C.A potent peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction. Circulation 107:896-904

Liaudet L, Szabó C, Evgenov O, Murthy KG, Pacher P, Virág L, Mabley J, Marton A, Soriano FG, Kirov M, Bjertnaes LJ, Salzman AL (2003) Flagellin from gram-negative bacteria is a potent mediator of acute pulmonary inflammation in sepsis. Shock, 19: 131-137.

Scott GS, Virag L, Szabo C, Hooper DC. Peroxynitrite-induced oligodendrocyte toxicity is not dependent on poly(ADP-ribose) polymerase activation. Glia 2003 Jan 15;41(2):105-116

Related documents

Kerekgyarto C, Virag L, Tanko L, Chihara G, Fachet J. Strain differences in the cytotoxic activity and TNF production of murine macrophages stimulated by lentinan. Int J Immunopharmacol. 1996 Jun-Jul;18(6-7):347-53.

Virag L, Kerekgyarto C, Fachet J. A simple, rapid and sensitive fluorimetric assay for the measurement of cell-mediated cytotoxicity. J Immunol Methods. 1995 Sep 25;185(2):199-208.

Virag L, Imre S. [Auto-oxidation test for the determination of lipid peroxidation capacity of liver tissue homogenates of young and old mice] Z Gerontol. 1991 Nov-Dec;24(6):319-22. German.

Ajuebor MN, Virag L, Flower RJ, Perretti M, Szabo C. Role of inducible nitric oxide synthase in the regulation of neutrophil migration in zymosan-induced inflammation. Immunology. 1998 Dec;95(4):625-30.

Virag L, Marmer DJ, Szabo C. Crucial role of apopain in the peroxynitrite-induced apoptotic DNA fragmentation. Free Radic Biol Med. 1998 Dec;25(9):1075-82.

Zingarelli B, Virag L, Szabo A, Cuzzocrea S, Salzman AL, Szabo C. Oxidation, tyrosine nitration and cytostasis induction in the absence of inducible nitric oxide synthase. Int J Mol Med. 1998 May;1(5):787-95.

Szabo C, Scott GS, Virag L, Egnaczyk G, Salzman AL, Shanley TP, Hasko G. Suppression of macrophage inflammatory protein (MIP)-1alpha production and collagen-induced arthritis by adenosine receptor agonists. Br J Pharmacol. 1998 Sep;125(2):379-87.

Downing JE, Virag L, Jones IW. NADPH diaphorase-positive dendritic profiles in rat thymus are discrete from autofluorescent cells, immunoreactive for inducible nitric oxide synthase, and show strain-specific abundance differences. Immunology. 1998 Sep;95(1):148-55.

Virag L, Scott GS, Cuzzocrea S, Marmer D, Salzman AL, Szabo C. Peroxynitrite-induced thymocyte apoptosis: the role of caspases and poly (ADP-ribose) synthetase (PARS) activation. Immunology. 1998 Jul;94(3):345-55.

Virag L, Salzman AL, Szabo C. Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death. J Immunol. 1998 Oct 1;161(7):3753-9.

Virag L, Hasko G, Salzman AL, Szabo C. NADPH diaphorase histochemistry detects inducible nitric oxide synthetase activity in the thymus of naive and staphylococcal enterotoxin B-stimulated mice. J Histochem Cytochem. 1998 Jul;46(7):787-91.

Gilad E, Wong HR, Zingarelli B, Virag L, O'Connor M, Salzman AL, Szabo C. Melatonin inhibits expression of the inducible isoform of nitric oxide synthase in murine macrophages: role of inhibition of NFkappaB activation. FASEB J. 1998 Jun;12(9):685-93.

Hasko G, Virag L, Egnaczyk G, Salzman AL, Szabo C. The crucial role of IL-10 in the suppression of the immunological response in mice exposed to staphylococcal enterotoxin B. Eur J Immunol. 1998 Apr;28(4):1417-25.

Downing JE, Virag L, Perry ME. Nitrergic mechanism of DC-mediated T-cell elimination. Immunol Today. 1998 Apr;19(4):190-1.

Szabo C, Virag L, Cuzzocrea S, Scott GS, Hake P, O'Connor MP, Zingarelli B, Salzman A, Kun E. Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3867-72.

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